Study on Smoking Bans Mischaracterizes Medical Data

Study on Smoking Bans Mischaracterizes Medical Data
December 14, 2012

Dr. John Dale Dunn, M.D., J.D.

John Dale Dunn, M.D., J.D. is a policy advisor for The Heartland Institute and the American Council... (read full bio)

Authors of a widely reported article on the health impacts of a local ban on smoking in restaurants claim their research shows significant health benefits, but the data examined in the article show no health benefits at all.

Conflicts of Interest

Richard D. Hurt, M.D., and colleagues published an article in Archives of Internal Medicine on the health effects of a smoking ban in restaurants (2002) and bars (2007) in Olmsted County, Minnesota, home of the Mayo Clinic in Rochester. The research was presented in 2011 at a meeting of the American Heart Association and published in Archives of Internal Medicine.

The authors claimed no conflicts of interest, but their study was financed by a smoking ban advocacy group ClearWay of Minnesota, and government smoking ban entities, the National Heart, Lung, and Blood Institute; and the National Institute on Aging. It is hard to imagine the authors receiving future government money to conduct studies if they didn’t report health benefits for the bans already enacted.

Methods and Results

The authors claimed their study showed a benefit from a 2002 smoking ban for restaurants and a 2007 smoking ban for bars. They studied rates of myocardial infarction (also known as MI’s or heart attacks) for 18 months before and after the bans. They also studied rates of what they called sudden cardiac death, using a “soft” definition, obtained from death certificates without autopsy in the majority of cases. 

The Patient Profiles from Table 1 in the article show:

MI’s occurred in a patient population mean age 67, 67 percent hypertensive, 22 percent diabetic, and 25 percent smokers. 

The sudden death group were mean age 77, 73 percent hypertensive, 24 percent diabetic, and 15 percent smokers. 

Table 2 is quite telling and includes their results on rates of MI and sudden death. 

Table 2. Incidence Rates and Relative Risks of MI and SCD 18 Months Before and After Implementation of Smoke-Free Laws
Before After

Characteristic No. Rate per 100 000 (95% CI) a No. Rate per 100 000 (95% CI) a Adjusted RR, (95% CI) a P ValueMI Ordinance 1 187 150.8 (129.0-172.6) 185 144.6 (123.6-165.5) 0.96 (0.78-1.18) .71Ordinance 2 206 152.3 (131.4-173.3) 139 100.7 (83.8-117.5) 0.66 (0.53-0.82) <.001Before Ordinance 1 vs after Ordinance 2 187 150.8 (129.0-172.6) 139 100.7 (83.8-117.5) 0.67 (0.53-0.83) <.001SCD Ordinance 1 143 109.1 (91.0-127.2) 148 112.7 (94.3-131.0) 1.01 (0.80-1.27) .96Ordinance 2 111 78.8 (64.0-93.5) 133 b 92.0 (75.7-108.3) 1.17 (0.91-1.51) .22Before Ordinance 1 vs after Ordinance 2 143 109.1 (91.0-127.2) 133 92.0 (75.7-108.3) 0.83 (0.65-1.06) .13Abbreviations: MI, myocardial infarction;  RR, relative risk; SCD, sudden cardiac death.a Adjusted for age and sex.b Cause of death was missing for 3.7% of out-of-hospital  deaths. The number reported herein represents the estimated number of SCDs obtained via multiple imputation for missing data.

Data ‘Clearly Unreliable’

There are important factors that jump out in Table 2 and the paper as a whole:

1. The Hurt paper is an analysis of data, not a toxicology study. The authors have no information other than hospital records and death certificates, so they cannot describe the exposures to cigarette smoke pre- and post-ban for the individuals who died or the individuals who had a myocardial infraction.

2. The basic data are clearly unreliable. The data have adjusted relative risks (RRs) less than 1 for all the acute myocardial infarction results. The data have a 1.01 RR post restaurant ban on sudden death, which has a p value (statistical probability that an event occurred by chance alone) of .96 that makes the result unreliable. The bar ban produced an association with sudden death of 1.17, but again the p value, 0.22, shows the result as unreliable. In all of the results, the Confidence Interval included 1, so the results all had a range of error or accuracy that included RR of 1 which means no effect is in the range or error or confidence. This study should have never been published. It proves nothing at all. 

3. Despite the authors’ claims, there are no studies that demonstrate credible and plausible explanations for an assertion that inhaled secondhand smoke causes death acutely or MI. The studies cited by the authors all include the same methodological and statistical deceptions that taint this study, including small associations rather than evidence of causation, and in many cases containing confidence intervals including 1. This systematic deceit is the product of a very well-financed and powerful crusade in which anti-smoking activists justify the use of flawed analyses by the asserted noble result of restricting smoking.

4. The authors propose the smoking ban reduced deaths and myocardial infarctions because the ban made smoking inconvenient and less frequent, although the authors present no evidence of this effect. The authors cannot know who was smoking or not smoking at home or in the car, and what effect a smoking ban might have on smoking habits. In addition, the myocardial infarctions and sudden deaths tended to occur in people past age 60, and the smoking rates were 25 percent and 15 percent, respectively. This invites the question, what should we blame for the nonsmoker deaths and MIs, and isn’t that potentially a predominant factor and a confounder when a study attempts to attribute rate changes to smoking bans?

Better Evidence Elsewhere

A more comprehensive and reliable study on smoking bans, national in scope for 15 years, was published in 2011 by the National Bureau of Economic Research and the Rand Corporation.  
Dr. Kanaka Shetty, M.D., and a team of health researchers reviewed deaths and hospitalizations over a 15-year period throughout the United States, looking for health effects of smoking bans all across the nation. The researchers reported, “In contrast with smaller regional studies, we find that smoking bans are not associated with statistically significant short-term declines in mortality or hospital admissions for myocardial infarction or other diseases. An analysis simulating smaller studies using subsamples reveals that large short-term increases in myocardial infarction incidence following a smoking ban are as common as the large decreases reported in the published literature.”

 

 

The authors further explained:

“We find no evidence that legislated U.S. smoking bans were associated with short-term reductions in hospital admissions for acute myocardial infarction or other diseases in the elderly, children, or working-age adults. We do not have data on smoking exposure changes for most regions, which makes elucidation of why the aggregate outcomes were null impossible. As such, it remains possible that smoking bans could improve public health outcomes in areas that have limited private restrictions and high baseline smoking rates (such as Scotland); in such cases, public bans might dramatically decrease ETS exposure and adverse health outcomes. However, our results argue against extrapolating from previously published results to typical U.S. cities.”

Shetty Study’s Significance

The Shetty study powerfully revealed flaws in cherry-picked studies like the Hurt paper. It proves the noise made by the Hurt paper this year and other “studies” regarding bans in places such as Pueblo, Colorado and Helena, Montana were a the product of cherry-picking—the deliberate choosing of data that will support a position.

The truth is sound medical studies show smoking bans in restaurants and bars don’t have any effect on human health. A key reason for this is secondhand smoke has no significant impact on human health. Importantly, the negative effects of smoking on human health are long-term and chronic, not acute. 

Dr. Jerome Arnett, Jr., MD (jerry.arnett@gmail.com) is a pulmonologist in Helvetia, West Virginia. Dr. John Dale Dunn, MD JD (jddmdjd@web-access.net) is an emergency physician in Brownwood, Texas.

Internet Info:

Shetty K., Deleire T., White C,. et al., “Changes in U.S. Hospitalization and Mortality Rates Following Smoking Bans,” Journal of Policy Analysis and Managementhttp://www.eufumo.com.br/publicacoes/changes-in-US-Hospitalization-and-mortality-rates-following-smoking-bans-2010.pdf and http://onlinelibrary.wiley.com/doi/10.1002/pam.20548/full

Richard D. Hurt, MD, Susan A. Weston, MS, Jon O. Ebbert, MD, et al., “Myocardial Infarction and Sudden Cardiac Death in Olmsted County, Minnesota, Before and After Smoke-Free Workplace Laws,” http://archinte.jamanetwork.com/article.aspx?articleid=1387590 

Dr. John Dale Dunn, M.D., J.D.

John Dale Dunn, M.D., J.D. is a policy advisor for The Heartland Institute and the American Council... (read full bio)